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July 21, 2011
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We demonstrate the metalation, purification, and characterization of lanthanide complexes. The complexes described here can be conjugated to macromolecules to enable tracking of these molecules using magnetic resonance imaging.
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PreparationPurificationCharacterizationLanthanide ComplexesContrast AgentsMagnetic Resonance ImagingPolyaminopolycarboxylate-based LigandsChelateFunctional GroupsConjugationAmine-reactive Activated EstersIsothiocyanate GroupsThiol-reactive MaleimidesMetalation ProceduresMetal Starting MaterialsPurification MethodsBiomedical Scientists
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Averill, D. J., Garcia, J., Siriwardena-Mahanama, B. N., Vithanarachchi, S. M., Allen, M. J. Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging. J. Vis. Exp. (53), e2844, doi:10.3791/2844 (2011).
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