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JoVE Journal
Biology

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Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy
 

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

Article DOI: 10.3791/2911
August 28th, 2011

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Summary August 28th, 2011

The stiffness of the extracellular matrix strongly influences multiple behaviors of adherent cells. Matrix stiffness varies spatially throughout a tissue, and undergoes modification in various disease conditions. Here we develop methods to characterize spatial variations in stiffness in normal and fibrotic mouse lung tissue using atomic force microscopy microindentation.

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