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Chapters
- 00:05Title
- 01:52Placement of Femoral Arterial and Venous Catheters
- 03:20Establish Mechanical Ventilation
- 04:12Placement of Flow Probes at Superior Mesenteric and Left Renal Arteries
- 07:13Hypoxia and Reoxygenation Protocol
- 08:48Typical Changes in Hemodynamic Parameters During Hypoxia
- 09:57Conclusion
Modelos animais de grande porte têm bons valores de translação no exame de fisiologia e farmacologia da asfixia neonatal. Usando leitões recém-nascidos, desenvolvemos um protocolo experimental para simular a asfixia neonatal, que tem as vantagens de estudar a hemodinâmica sistêmica e regional, o transporte de oxigênio com vias bioquímicas e patológicas e correlações.
Tags
Swine ModelNeonatal AsphyxiaMulti-organ FailureHypotensionPerfusion DeficitHypoxic-ischemic EncephalopathyPulmonary HypertensionVasculopathic EnterocolitisRenal FailureThrombo-embolic ComplicationsAnimal ModelsPatho-physiologyPharmacologyNewborn PigletBody SystemsHemodynamic ChangesInterventionsMulti-organ FailureDysfunctionSurgical InstrumentationMechanical VentilationVascular
