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JoVE Journal
Medicine
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
JoVE Journal
Medicine
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JoVE Journal Medicine
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Full Text
25,940 Views
12:21 min
September 12, 2011

DOI: 10.3791/3178-v

Rajesh K. Kana1, Donna L. Murdaugh1, Lauren E. Libero1, Mark R. Pennick1, Heather M. Wadsworth1, Rishi Deshpande1, Christi P. Hu1

1Department of Psychology,University of Alabama at Birmingham

Neuroimaging techniques, such as functional MRI and Diffusion Tensor Imaging have become increasingly useful in characterizing the cognitive and neural deficits in autism. An examination of brain connectivity in autism at a network level along with adaptations for scanning children with developmental disabilities is presented.

The overall goal of the following experiment is to examine the connections among brain areas that are important for social cognition in autism. Using functional MRI and diffusion tensor imaging of the brain in both children and adults with autism, this is achieved by designing appropriate FMRI experiments, then recruiting autistic participants. The participants must be adequately prepared for the procedure to obtain quality, functional and structural brain images.

The functional experiments are presented to the participant in the MRI scanner while performing a predefined task. The MR Images acquired result in a relatively large amount of data for each experiment. The acquired neuroimaging data are transferred to the lab's computer server, then pre-processed and subjected to statistical analysis by creating models.

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