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JoVE Journal
Immunology and Infection
Author Produced

This content is Open Access.

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
 

Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model

Article doi: 10.3791/3716
July 29th, 2012

Summary July 29th, 2012

The inoculation of Trypanosoma cruzi in fertile eggs prior to incubation renders the parasite kDNA minicircle integration in embryo cells genome. Crossbreeding reveals the vertical transfer of the mutations to progeny. The kDNA integrates into coding regions at several chromosomes and the chickens die with an inflammatory autoimmune heart disease.

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