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Biology

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Synthesis of an In vivo MRI-detectable Apoptosis Probe
 

Synthesis of an In vivo MRI-detectable Apoptosis Probe

Article DOI: 10.3791/3775
July 31st, 2012

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Summary July 31st, 2012

Early detection of apoptosis may identify at-risk cell populations in a variety of diseases. Here we demonstrate a method to link an early apoptosis-detection protein (Annexin V) to a MRI-detectable iron oxide nanoparticle (SPIO). This method may be extended to other proteins of interest to generate MRI-detectable molecular imaging probes.

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