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JoVE Journal
Medicine

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The Use of Pharmacological-challenge fMRI in Pre-clinical Research
 

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

Article DOI: 10.3791/3956
April 25th, 2012

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Summary April 25th, 2012

The goal of this technique is to assess serotonin (5-HT) neurotransmitter function in the live and free-breathing animal with pharmacological magnetic resonance imaging (phMRI) and an intravenous challenge with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.

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