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JoVE Journal Medicine
Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
 

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Article doi: 10.3791/4016
November 28th, 2012 •
1,2, 2, 2
1St. Erik's Eye Hospital, Karolinska Institutet, 2Gullstrand lab, Section for Ophthalmology, Department of Neuroscience, Uppsala University

Summary
Automatic Translation
November 28th, 2012

Cataract is the leading cause of blindness in the world. Solar ultraviolet radiation (UVR) is the main risk factor for cataract development. An animal model of far UVR-B induced cataract was developed. In this article we describe methods for investigation of cataract formation: exposure to UVR, quantitative RT-PCR and immunohistochemistry.

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