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In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
 

In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes

Article DOI: 10.3791/4091
August 13th, 2012

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Summary August 13th, 2012

Cystic fibrosis transmembrane conductance regulator (CFTR), an epithelial chloride channel, has been reported to interact with various proteins and regulate important cellular processes; among them the CFTR PDZ motif-mediated interactions have been well documented. This protocol describes methods we developed to assemble a PDZ-dependent CFTR macromolecular signaling complex in vitro.

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