Medicine
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Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
Chapters
Summary August 28th, 2012
A method for large-scale purification of the APP intracellular domain (AICD) is described. We also describe methodology to induce in vitro AICD aggregation and visualization by atomic force microscopy. The methods described are useful for biochemical/structural characterization of the AICD and the effects of molecular chaperones on its aggregation.
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