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JoVE Journal
Immunology and Infection
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Granulocyte-dependent Autoantibody-induced Skin Blistering
 

Granulocyte-dependent Autoantibody-induced Skin Blistering

Article DOI: 10.3791/4250
October 12th, 2012

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Summary October 12th, 2012

In the animal model described in our present work, purified IgG antibodies against a stretch of 200 amino acids (aa 757-967) of collagen VII are injected repeatedly into mice reproducing the blistering phenotype as well as the histo- and immunopathological features characteristic to human epidermolysis bullosa acquisita (EBA)1.

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