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Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Article DOI: 10.3791/4251-v • 10:24 min • September 28th, 2012
September 28th, 2012 •
1,2, 3, 1,2,4
1Department of Radiation Oncology, Virginia Commonwealth University, 2Department of Biochemistry & Molecular Biology, Virginia Commonwealth University, 3Department of Anatomy & Neurobiology, Virginia Commonwealth University, 4Massey Cancer Center, Virginia Commonwealth University

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Summary
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This protocol describes a method for visualizing a DNA double-strand break signaling protein activated in response to DNA damage as well as its localization during mitosis.

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Two-dimensional Three-dimensional Live Cell Imaging DNA Damage Response Proteins Double-strand Breaks Mutations Chromosomal Aberrations Genomic Instability DNA Damage Response Cell Cycle Arrest Apoptosis Nonhomologous End-joining Homologous Recombination Repair Proteins 53BP1 P53-binding Protein 1 Modified Histones Foci Histone Modifications Chromatin Rearrangement
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