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Quantitative Analysis of Chromatin Proteomes in Disease
JoVE Journal
Medicine
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JoVE Journal Medicine
Quantitative Analysis of Chromatin Proteomes in Disease

Quantitative Analysis of Chromatin Proteomes in Disease

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08:11 min

December 28, 2012

DOI:

08:11 min
December 28, 2012

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Summary

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Advances in mass spectrometry have allowed the high throughput analysis of protein expression and modification in a host of tissues. Combined with subcellular fractionation and disease models, quantitative mass spectrometry and bioinformatics can reveal new properties in biological systems. The method described herein analyzes chromatin-associated proteins in the setting of heart disease and is readily applicable to other in vivo models of human disease.

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