Name: Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity (Video) | JoVE Journal
Uploaded: 2013-01-10T13:00:00.000+00:00
Duration: 11 min 34 s
Description: Learn BreEStim for managing neuropathic pain and spasticity using breathing-controlled electrical stimulation. This method synchronizes voluntary inhalation with targeted pulses to enhance therapeutic efficacy and improve patient outcomes.

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This study was supported in part by NIH grants (NIH/NINDS R01NS060774; NIH/NICHD/NCMRR R24 HD050821-08 under subcontract with Rehabilitation Institute of Chicago). The author thanks Craig Ditommaso, MD for his editing and helpful suggestions.

The following BreEStim protocol could be applied for both finger flexor spasticity and neuropathic pain management. The main difference lies in surface electrode placement and adjustment of stimulation intensity. These differences are explained in detail for each application.
1. Subject Preparation and Setup
<ol>
	<li>Seat the subject comfortably. Place the arms and hands comfortably on the treatment table.</li>
	<li>Identify and localize the area of interest for surface electrode placement.
	<ol>
		<li>For spasticity management, palpate the muscle belly of finger extensors and confirm with electrical stimulation.</li>
		<li>For pain management, locate acupuncture points of Neiguan and Weiguan on the forearm24 ipsilateral to the side of interest, e.g., amputation17, or on the side with more symptoms, e.g., SCI. Neiguan is located about 3-finger width above the wrist crease on the volar side and in the middle between medial and lateral boards of the forearm (i.e., distal 1/6 of the forearm)24 (Figure 3). Weiguan is the counterpart of Neiguan, located in the dorsal aspect of the forearm24.</li>
	</ol>
	</li>
	<li>Trim each self-adhesive electrode to about a 2cm x 2cm square to provide focal and isolated electrical stimulation.
	<ol>
		<li>For spasticity management, place the cathode over the finger extensor muscle belly (Figure 4). Attach the anode to a site 1~2 cm distal to the cathode. Optimize the sites for the anode and cathode when eliciting the largest and isolated finger extension response with a minimal wrist response.</li>
		<li>For pain management, place the cathode electrode on Neiguan, and the anode electrode on Weiguan.</li>
	</ol>
	</li>
	<li>Connect surface electrodes to the electrical stimulator (Digitimer DS7A, UK, <a href="http://www.digitimer.com" target="_blank">www.digitimer.com</a>).</li>
	<li>Place and secure facemask. Select the size of facemask carefully to fit individual's face to prevent air leakage and to provide comfort of wearing the mask (Figure 5).</li>
	<li>Connect facemask to a pneumotach system (Series 1110A, Hans Rodolph Inc; Kansas City, Missouri; <a href="http://www.rudolphkc.com" target="_blank">http://www.rudolphkc.com</a>).</li>
</ol>
2. Instruction on Voluntary Breathing
Voluntary breathing, particularly voluntary inhalation, plays a critical role in this intervention. Voluntary inhalation is defined as effortful deep and fast inhalation. Instruct the subject to take a single isolated deep breath, similar to routine deep breaths, but faster and stronger. There is no need to perform voluntary exhalation preceding forced inhalation in a breathing cycle. Allow the subject to have 8~10 practice trials to understand the instructions.
3. Electrical Stimulation Settings
<ol>
	<li>Set a single electrical stimulus as a single square-wave pulse with 0.1ms duration. The intensity of electrical stimulation is different for different applications. Since a single electrical stimulus is delivered each time, there is no need to set frequency parameter.</li>
	<li>For spasticity management, determine the intensity of electrical stimulation when 1) isolated finger extension responses are elicited with minimal involvement of wrist joint responses; 2) the highest level that the subject could tolerate. The absolute magnitude of stimulation intensity could be different for different subjects. Encourage the highest intensity that the subject could tolerate to achieve the best outcome.</li>
	<li>For pain management, allow the subject to determine incremental changes of the stimulation intensity. The starting intensity is zero. The highest level is the maximal output of the stimulator or the level the subject could tolerate. However, explicitly instruct the subject that discomfort or painfulness, even "aversiveness" of electrical stimulation is part of treatment; therefore, encourage the subject to select the highest level that the subject could tolerate.</li>
</ol>
4. Control of Electrical Stimulation
<ol>
	<li>Write a customized LabView (National Instrument, Austin, TX) program to control delivery of electrical stimulation in two ways: BreEStim and EStim.</li>
	<li>Breathing-controlled electrical stimulation (BreEStim) (Figure 6):
	<ol>
		<li>Determine the peak airflow rate during voluntary inhalation, i.e., during the deepest and fast inhalation.</li>
		<li>Determine the threshold which is 40% peak airflow rate. Of note, set the threshold higher than the airflow rate during normal breathing to encourage deeper and faster voluntary breathing.</li>
		<li>Then set the trigger function. When the instantaneous airflow rate of an isolated voluntary inhalation reaches or beyond the threshold, the LabView program triggers and delivers a single electrical stimulus with preset duration and intensity16. Allow the subject to rest upon request.</li>
	</ol>
	</li>
	<li>Randomly-triggered electrical stimulation (EStim):
	<ol>
		<li>Allow the subject breathe normally without specific instructions on breathing.</li>
		<li>The LabView program randomly delivers a single electrical stimulus with preset duration and intensity every 4 to 7 sec. Similarly, allow the subject to rest upon request.</li>
	</ol>
	</li>
</ol>
5. Dose of BreEStim
It is recommended that each session of treatment has 100 to 120 BreEStim stimuli. It lasts approximately 30-40 min.
6. Recording and Monitoring
<ol>
	<li>Make sure there is no air leakage from the facemask, since voluntary inhalation plays an important role in this protocol.</li>
	<li>Monitor signs of hypoxemia and hyperventilation when the subject wears facemask. Allow rest at the subject's request for this purpose.</li>
	<li>Record any side effect, tolerance of voluntary breathing via a face mask, and any psycho-social effects.</li>
	<li>For pain management, record any reduction of pain, i.e., visual analogue scores (VAS) 57 and duration of the effect. Use the modified VAS (mVAS) to further quantify the effect of pain reduction, i.e., how much pain is reduced and how long it lasts (reduction &times; hours). Also record the average intensity for each session, since the intensity of electrical stimulation varies during each session of treatment.</li>
	<li>For spasticity management, record the Modified Ashworth Scale (MAS) value of the target muscle and other clinical measurements, including strength, sensation, and range of motion.</li>
</ol>

Method and apparatus of breathing-controlled electrical simulation for skeletal muscles (inventor: S.L., pending patent, application number 12146176).

Breathing-controlled electrical stimulation (BreEStim), as shown in the above two cases, has demonstrated clinical efficacy in spasticity management and subsequent hand function recovery in chronic stroke patients16, as well as management of neuropathic pain of central origin in the above patient with a spinal cord injury or of peripheral origin in a patient with above-the-knee amputation17. This enhanced clinical outcome and broader clinical applications of BreEStim are attributed to its unique approach. Intervention with electrical stimulation targeted at the short window of voluntary breathing-associated cortical and subcortical activation 40-51 could augment its clinical efficacy via intrinsic physiological coupling, e.g., respiratory-motor coupling for spasticity management16. In this intervention, voluntary breathing becomes critical, particularly voluntary inspiration. Education for patients on proper breathing techniques and accurate measurement of breathing parameters (e.g., no air leakage) are measures to prevent failure of the BreEStim intervention.
The new intervention protocol - BreEStim, has a few advantages, in addition to better efficacy and broader applications.
BreEStim is patient-centered. BreEStim encourages active engagement of patients since voluntary breathing is required 17. Patients feel they actively participate in managing their pain, rather than "a passive participant in their own care". For example, the patient controls the intensity of electrical stimulation, starting from zero to the highest level that the patient could tolerate17. This may enhance their treatment compliance. EMG-triggered EStim also involves active participation36, but the patient can not control the intensity of electrical stimulation.
BreEStim takes an integrative, system-based approach. As demonstrated in an earlier study17, different pain coping mechanisms are integrated into one protocol, including electrical stimulation, acupuncture, aversive stimulation, and the systemic effects of voluntary breathing. As such, patients are able to tolerate high levels of electrical stimulation, leading to enhanced analgesic effects. Such a positive feedback loop (activation of the reward system) results in greater clinical efficacy. Using this integrative, system-based approach, certain signals of voluntary breathing could also be used to identify the time window of interactions between systems. As such, BreEStim could be applied to patients with severe spasticity. These patients are usually not able to perform voluntary contraction, thus "clean" EMG signals from the target muscle are not available. In EMG-triggered electrical stimulation, EMG signals from the targeted muscles (e.g., finger extensors) are required to trigger electrical stimulation. Therefore, application of EMG-triggered EStim is limited to patients with mild to moderate spasticity.
BreEStim is a non-invasive, non-pharmacological treatment. This is critical because patients often require a long-term use of medications, and most medications for chronic pain and spasticity have side effects that can sometimes be very severe. The possible side effects include addiction, overdose, withdrawal symptoms, and constipation, etc. These potential side effects could be avoided in the BreEStim treatment.
BreEStim is an alternative choice. The alternative non-pharmacological treatment with better analgesic effects is important, particularly when neuropathic pain is difficult to manage. For example, only 7% of responders reported pharmacological treatment is effective for neuropathic pain following SCI in a postal survey 58.
In summary, this breathing-driven stimulation, BreEStim, is based on the newly discovered phenomenon of intrinsic physiological coupling activated during voluntary breathing. The BreEStim protocol has demonstrated clinical efficacy for neuropathic pain and post-stroke spasticity management. Further research is warranted to examine underlying mechanisms that mediate the intervention effect. Importantly, there may be other applications that have not yet discerned.

Electrical stimulation (EStim) refers to the application of electrical current to muscles or nerves in order to achieve functional and therapeutic goals. It has been extensively used in various clinical settings, e.g., transcutaneous electrical nerve stimulation (TENS) for pain management1, peroneal nerve stimulation for foot drop2, neuromuscular electrical stimulation (NMES) for activation and strengthening of paralyzed or weakened muscles3. When NMES is used to achieve a functional task, it is termed functional electrical stimulation (FES)4. Electromyogram (EMG)-triggered neuromuscular stimulation has been used to augment effectiveness of electrical stimulation in motor recovery 5-14 and spasticity reduction after stroke 7, 15. In this paper, a new EStim protocol - Breathing-controlled electrical stimulation (BreEStim), is introduced, according to recent research findings on the systemic effect of voluntary breathing16, 17.
Transcutaneous electrical nerve stimulation (TENS) is a non-pharmacological modality for pain management1. TENS is noninvasive, inexpensive, safe and easy to use18. TENS is usually applied at varying frequencies, intensities, and pulse durations of stimuli for a prescribed treatment time. TENS has been applied to a variety of pain conditions, including neuropathic pain. The clinical effectiveness of TENS is controversial, particularly in spinal cord injury (SCI) and amputation (see Reviews 1, 19, 20). The possible mechanisms are the gate control theory 21 and the release of endogenous opioids 22, 23. Acupuncture from Traditional Chinese Medicine is another non-pharmacological modality for pain management. It has been well accepted in Western Medicine24. In modern acupuncture, the traditional acupuncture needle has been replaced by a surface electrode (or equivalent). A specialized electrode is place over traditional acupoints and an electrical stimulation is delivered. This modification has been termed electroacupuncture25, 26. Needle acupuncture and electroacupuncture are both effective in analgesia via the release of endogenous opioids 27, 28. The effect of electroacupuncture is usually reliable, however the effect is dependent on intensity and frequency of delivered electrical stimulation. Different frequencies of electrical stimulation generate different endogenous opioids, and the analgesic effect is naloxone-reversible 26, 27. Recently, it has been found that repetitive painful stimulation (aversiveness) leads to significant pain attenuation. The induced pain attenuation is not naloxone-reversible 29. Integrating of these pain coping mechanisms (acupuncture, electrical stimulation, aversiveness) into a possible new intervention could improve its clinical efficacy.
EMG-triggered neuromuscular stimulation has been used for many years to facilitate post-stroke motor recovery of finger extension impairments 5-10, 12-14, 34. Recovery of hand function is important for stroke patients, and yet is very challenging. Roughly one third of all people who experience a stroke will have some residual impairment of the upper extremity 30-32, with major impairments in hand function 33. The EMG-triggered NMES intervention protocol involves initiation of a voluntary contraction of extensor muscles for a specific movement until the muscle activity reaches a threshold level. As soon as the EMG activity reaches a target threshold, an assisting electrical stimulus begins to facilitate the movements. This intervention protocol is superior to regular NMES in motor recovery6, 7. Chae and Yu 35 stated that all randomized controlled studies reported improvement in motor function using this intervention protocol, with mild to moderately impaired patients improving the most. It is most likely that this intervention takes advantage of active engagement of patients (by setting a target EMG threshold) and this results in measureable changes in recovery as well as documented changes in the cortex6, 7. This is supported by a recent functional MRI study that showed a significant increase in cortical intensity in the ipsilateral somatosensory cortex after treatment in the NMES group, as compared with the control group36. Furthermore, electrical stimulation may also help to reduce spasticity after stroke7, 15, but the effect is short-lasting, about 30 min after EStim37. In contrast, our recent invention of breathing-controlled electrical stimulation (BreEStim) has a long-lasting effect on spasticity reduction, even after a single session of treatment 16.
Human breathing is a very unique motor act. It can be controlled reflexively (automatic breathing), e.g., during sleep, and also voluntarily when needed (voluntary breathing), e.g., singing, speech, etc. During voluntary breathing, humans need to voluntarily suppress autonomic control of breathing through voluntary cortical activation (the "cortical respiratory center") 38, 39. Brain imaging studies 40-51 have demonstrated extensive respiratory-related involvement of cortical areas bilaterally, including the primary motor cortex (M1), the premotor cortex, the supplementary motor area, the primary and secondary somatosensory cortices, the insula, the anterior cingulate cortex and amygdala, and the dorsolateral prefrontal cortex. The insula is known to have strong connections to brainstem centers and is involved in pain processing 52. During autonomic breathing, inspiration is active while expiration is passive, mainly relying on recoil force of the chest wall. Similarly, volitional inspiration activates more respiratory-related cortical and subcortical areas when compared to volitional expiration 46. These cortical and subcortical areas activated during voluntary breathing are also involved in different functions 53, such as muscle tone, pain, posture, mood, speech, etc. Therefore, it is not unreasonable to associate interactions in breathing with modulation of other functions.
Recently, we have discovered that there exist interactions between respiratory and motor systems during voluntary breathing. Specifically, there is a finger extension-inspiration coupling 16, 54-56. When electrical stimulation is delivered to the finger extensors during the inspiratory phase of voluntary breathing, a long-lasting effect of reduction in finger flexor spasticity (muscle tone) in chronic stroke patient is observed 16. In another study 17, shooting phantom pain in a patient with an above-the-knee amputation disappeared after the BreEStim treatment, but re-appeared 28 days later after receiving a sustained electrical stimulation accidentally. This case study provides a unique opportunity to understand that the affective component of noxious stimuli of neuropathic pain (shooting phantom pain) has been modified by the BreEStim treatment, but then re-triggered by an accidental stimulation. These observations of tone and pain reduction have demonstrated that voluntary breathing, inspiration in particular, could be integrated into an electrical stimulation paradigm to improve its efficacy in neuropathic pain management and post-stroke spasticity management.
Case Presentations
Case 1: Post-stroke Spasticity Management
The patient was a 69 years-old male who had right hemiplegia secondary to a stroke 22 months ago. He was medically stable and had been discharged from outpatient physical and occupational therapy programs. No brain imaging results were available at the time of experiments. He had weakness on his right side but was able to walk independently without an assistive device. He had residual voluntary finger flexion and extension, but with limited active range of motion at his right metacarpophalangeal (MCP) joints, from 90 &deg; to 70 &deg; of MCP flexion, i.e., not able to sufficiently open his hand and fingers for functional use. Muscle tone of his right finger flexors was moderately increased. Modified Ashworth Scale (MAS) was 1+. Sensation of his right hand and fingers, however, was intact to light touch. He received approximately a 30-min BreEStim to the finger extensors. His finger flexor spasticity decreased to minimum (MAS=0) and voluntary finger extension became nearly normal immediately after the treatment. This patient regained his hand function as well. He reported that he could cut meat with a knife and button shirts using his impaired hand. More strikingly, the recovery retained at least 8 weeks during follow-up visits (Figure 1).
Case 2: Neuropathic Pain Management
The patient was a 40 years-old male who suffered a spinal cord injury 4.5 years ago in a motor vehicle accident, resulting in T8 ASIA A spinal cord injury. The patient complained of neuropathic pain at the injury level, while he had no other active medical issues. He had been stable on a pain regime for 2 weeks prior to the treatment. He received EStim (one session per day for five consecutive days) first, waited 1 week as a washout, and then received BreEStim with the same dose (one session per day for 5 consecutive days). Each treatment session consisted of 120 stimuli (EStim or BreEStim). Surface electrodes were placed on acupoints (Neiguan and Weiguan) of the right forearm. Modified Visual Analogue Scale (mVAS) was used to compare the effect of each intervention (EStim and BreEStim). As shown in Figure 2, BreEStim had a greater pain reduction effect than EStim, except for Day 2 during BreEStim when the patient had a urinary tract infection (UTI) which was successfully treated with antibiotics. The intensity of electrical stimulation was similar between EStim and BreEStim (Figure 2). He tolerated both interventions well (maximum output intensity from the stimulator was used), even during the UTI. During the entire experimental period (4 weeks), the subject maintained the same dose and schedule of pain medications. Both BreEStim and EStim treatment sessions were performed at the same time of the day (between 11 AM to Noon), such that changes in the pain rating could possibly be attributed to stimulation effects and not diurnal variation.

<table><tbody><tr><td>&lt;a href="http://digitimer.com/products/clinical-neurophysiology/ds7aah-psarp-peripheral-stimulators/
" target="_blank"&gt;Electrical stimulator&lt;/a&gt;</td><td><a href="http://www.digitimer.com" target="_blank"><img src="/img/new_window.png"> Digitimer</a></td><td>&lt;a href="http://digitimer.com/products/clinical-neurophysiology/ds7aah-psarp-peripheral-stimulators/ds7a-ds7ah-hv-constant-current-stimulator-clinical-product/" target="_blank"&gt;DS7A&lt;/a&gt;</td><td>&lt;a href="http://www.digitimer.com/" target="_blank"&gt;http://www.digitimer.com&lt;/a&gt;</td></tr><tr><td>Pneumotach system</td><td>Hans Rodolph Inc</td><td>Series 1110A</td><td>&lt;a href="http://www.rudolphkc.com/" target="_blank"&gt;http://www.rudolphkc.com&lt;/a&gt;</td></tr></tbody></table>

breathing-controlled electrical stimulation (breestim) for management of neuropathic pain and spasticity

Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity

Electrical stimulation (EStim) refers to the application of electrical current to muscles or nerves in order to achieve functional and therapeutic goals. It has been extensively used in various clinical settings. Based upon recent discoveries related to the systemic effects of voluntary breathing and intrinsic physiological interactions among systems during voluntary breathing, a new EStim protocol, Breathing-controlled Electrical Stimulation (BreEStim), has been developed to augment the effects of electrical stimulation. In BreEStim, a single-pulse electrical stimulus is triggered and delivered to the target area when the airflow rate of an isolated voluntary inspiration reaches the threshold. BreEStim integrates intrinsic physiological interactions that are activated during voluntary breathing and has demonstrated excellent clinical efficacy. Two representative applications of BreEStim are reported with detailed protocols: management of post-stroke finger flexor spasticity and neuropathic pain in spinal cord injury.

Breathing-controlled electrical stimulation (BreEStim) has demonstrated excellent clinical efficacy in management of neuropathic pain in spinal cord injury and post-stroke finger flexor spasticity. Spasticity reduction after BreEStim treatment depends on the severity of pretreatment conditions. As shown in Figure 1, the finger flexor spasticity was greatly reduced after BreEStim treatment. Finger flexor spasticity has been reduced from MAS 1+ to minimum (MAS=0). The patient is able to open his hand and fingers for functional use. It is important to note that other patients may not have the same degree of spasticity reduction and functional improvement. In a patient with severe finger flexor spasticity (MAS=3) and without residual voluntary finger extension (as shown in Figure 4), finger flexor spasticity was reduced to MAS=1. This makes it easier for the patient to range her fingers, but does not restore functional use of her hand.
BreEStim also demonstrates better and longer pain reduction effects. Figure 2 shows that with similar intensity of electrical stimulation, BreEStim has better outcome than regular electrical stimulation. However, BreEStim did not affect pain scores on Day 2 when the patient had a urinary tract infection. This suggests that BreEStim has no effect on pain reduction when pain is confounded by infection.
Voluntary breathing plays a key role in BreEStim. It is important to choose a facemask that fits the patient (Figure 5) to prevent air leakage. The airflow rate is relatively low during normal breathing (1.6 liter/sec, Figure 6). Forceful voluntary inhalation could greatly increase the airflow rate (about 8 liter/sec). Placement of surface electrodes is also important. As described in detail and shown in Figure 3 and Figure 4, placement for pain and spasticity management is different. It is necessary to note that location of muscle belly of finger extensors may change as a result of atrophy, deformity after stroke.
<img alt="Physical therapy progress, pre and post hand movement, rehabilitation therapy, patient exercise." src="/files/ftp_upload/50077/50077fig1.jpg" data-altupdatedat="1787630408000" data-alt="Figure 1"> 
 Figure 1. Comparison of hand posture pre- and post-BreEStim. The stroke patient could open his hand after BreEStim.
<img alt="Comparative graphs of BreEStim and EStim; effect vs. hours, stimulation intensity vs. days." fo:content-width="4.5in" fo:src="/files/ftp_upload/50077/50077fig2highres.jpg" src="/files/ftp_upload/50077/50077fig2.jpg" data-altupdatedat="1787630408000" data-alt="Figure 2"> 
 Figure 2. Comparison of BreEStim and EStim effects on pain reduction.
<img alt="Acupressure point Neiguan location, wrist diagram for stress relief and nausea relief methods." src="/files/ftp_upload/50077/50077fig3.jpg" data-altupdatedat="1787630408000" data-alt="Figure 3"> 
 Figure 3. Location of Neiguan. Note, Waiguan is the counterpart of Neiguan on the dorsal aspect of the forearm.
<img alt="Electromyography setup; electrodes on arm for muscle activity analysis; biomedical research." src="/files/ftp_upload/50077/50077fig4.jpg" data-altupdatedat="1787630408000" data-alt="Figure 4"> 
 Figure 4. Placement of surface electrodes on finger extensors.
<img alt="Metabolic cart setup, respiratory analysis experiment, physiological measurement, VO2 max testing." src="/files/ftp_upload/50077/50077fig5.jpg" data-altupdatedat="1787630408000" data-alt="Figure 5"> 
 Figure 5. A patient during BreEStim. Surface electrodes are placed on Neiguan and Waiguan.
<img alt="Airflow vs. Time graph showing voluntary and resting inspiration, with stimulation interruption effects." fo:content-width="4.5in" fo:src="/files/ftp_upload/50077/50077fig6highres.jpg" src="/files/ftp_upload/50077/50077fig6.jpg" data-altupdatedat="1787630408000" data-alt="Figure 6"> 
 Figure 6. real-time measurement of airflow rate during voluntary inspiration and resting inspiration. Note that the airflow rate is much higher during voluntary inspiration than resting inspiration. It is noticeable that patient's breathing was interrupted by electrical stimulation.

The purpose is to present a new method, breathing-control electrical stimulation (BreEStim) for management of neuropathic pain and spasticity.

Electrical stimulation (EStim) refers to the application of electrical current to muscles or nerves in order to achieve functional and therapeutic goals. ...

The overall goal of the following experiment is to improve therapeutic efficacy of electrical stimulation when it is triggered by voluntary breathing. This is achieved by monitoring breathing signals to detect voluntary breathing as a second step, the value of detected breathing signals is compared to the preset threshold, which determines whether a trigger needs to be sent. Next, a trigger is sent to the electrical stimulator in order to deliver an electrical pulse to the target areas that is synchronized with voluntary breathing.Results are obtained that show increased efficacy in pain relief and spasticity reduction based on breathing controlled electrical stimulation. The main advantage of this technique over existing methods like transcutaneous electrical nerve stimulation or tense, is that voluntary breathing controlled electrical stimulation or breathe stem integrates the intrinsic physiological coupling activated during voluntary breathing to improve therapeutic efficacy of electrical stimulation. To begin setup for stimulation, first, have the subject sit comfortably with arms and hands comfortably on the treatment table.Then identify and localize the area of interest for surface electrode placement. To perform BRI stim for pain management, first, locate the acupuncture points of Negan and waan on the forearm ipsilateral to the side of interest. Negan is located about three finger widths above the wrist crease on the voler side, and in the middle between medial and lateral boards of the forearm.Waan is the counterpart of Negan located in the dorsal aspect of the forearm. Trim each self-adhesive electrode to a two by two centimeter square to provide focal and isolated electrical stimulation and place the cathode electrode on nagu and the anode electrode on wagu to perform brief stim for spasticity management. Place the cathode over the finger, extensor muscle belly, and attach the anode to a site, one to two centimeters distal to the cathode.Then optimize the sites for the anode and cathode to the locations. Eliciting the largest isolated finger extension response with a minimal wrist response shown. Here is a photograph of a patient being treated with BRI stim for both treatment methods.Next, connect the surface electrodes to the electrical stimulator. Then place and secure the face mask. Select the size of the face mask carefully to fit the individual's face to prevent air leakage, and to provide comfort of wearing the mask, connect the face mask to a pneumatac system.Now again, for both treatment methods, provide the subject with instructions for voluntary breathing. Voluntary inhalation plays a critical role in this intervention and is defined as effortful. Deep and fast inhalation instruct the subject to take a single isolated deep breath, similar to routine deep breaths, but faster and stronger.There is no need to perform voluntary exhalation proceeding forced inhalation in a breathing cycle, allow the subject to have eight to 10 practice trials to understand and become comfortable with the instructions. Set a single electrical stimulus as a single square wave pulse with a 0.1 millisecond duration. There is no need to set a frequency parameter.The intensity of electrical stimulation is different for the different applications for pain management. Use zero as the starting intensity. Then allow the subject to determine incremental changes of the stimulation intensity.Determine the highest level, whether it is the maximal output of the stimulator or the level the subject can tolerate. Explicitly instruct the subject that discomfort or painfulness, even aversiveness to electrical stimulation is part of treatment. Therefore, encourage the subject to select the highest level that he or she can tolerate.For spasticity management. Determine the intensity of electrical stimulation at which isolated finger extension responses are elicited with minimal involvement of wrist joint responses. Also determine the highest intensity the subject can tolerate.Note that the absolute magnitude of stimulation intensity can differ between subjects. Again, encourage the highest intensity that the subject can tolerate to achieve the best outcome for both breathing controlled electrical stimulation and electrical stimulation. Write a customized lab view program to control delivery of stimulation.Here, the stimulation is demonstrated for pain management. Using BRI stim. Determine the peak airflow rate during voluntary inhalation IE during the deepest and fastest inhalation.Next, determine the threshold, which is 40%peak airflow rate. Set the threshold higher than the airflow rate during normal breathing to encourage deeper and faster voluntary breathing. Next, set the trigger function.When the instantaneous airflow rate of an isolated voluntary inhalation reaches or surpasses the threshold, the lab view program will trigger and deliver a single electrical stimulus with preset duration and intensity. Allow the subject to rest upon request to perform randomly triggered electrical stimulation. With e-stim, allow the subject to breathe normally without specific instructions.The lab view program will randomly deliver a single electrical stimulus with a preset duration and intensity every four to seven seconds. Similarly, allow the subject to rest upon request. Note that it is recommended that each session of treatment contains 100 to 120 brief stim stimuli and should last approximately 30 to 40 minutes to ensure accurate recording and monitoring during stimulation.Ensure that there is no air leakage from the face mask since voluntary inhalation plays an important role in this protocol. Closely monitor for signs of hypoxemia and hyperventilation while the subject wears the face mask. Be sure to allow rest at the subject's request for this purpose.Record any side effects, tolerance of voluntary breathing via the face mask and any psychosocial effects that may occur for pain management. Also, record any reduction of pain such as visual analog scores and duration of the effect. Also, record the average intensity for each session since the intensity of electrical stimulation varies during each session of treatment, use the modified visual analog scores to further quantify the effect of pain reduction, such as how much pain is reduced and the duration of reduction.This patient was a 40-year-old male who suffered a spinal cord injury 4.5 years ago in a motor vehicle accident resulting in a T eight Asia, a spinal cord injury. The patient complained of neuropathic pain at the injury level. While he had no other active medical issues, he had been stable on a pain regime for two weeks prior to the treatment he received E-stim first waited one week as a washout and then received breeze stim with the same dose.Each treatment session consisted of 120 stimuli surface electrodes were placed on acupoints of the right forearm. Modified visual analog scale was used to compare the effect of each intervention as seen. Here, BRI Stim had a greater pain reduction effect than E-stim except on day two when the patient had a urinary tract infection, which was successfully treated with antibiotics.The intensity of electrical stimulation was similar between E-stim and bti. The subject tolerated both interventions. Well, even during the UTI, the subject maintained the same dose and schedule of pain medications during the four week experimental period.Both STI and E-stim treatment sessions were performed at the same time of the day, such that changes in the pain rating could be attributed to stimulation effects and not diurnal variation. Here we see photographic evidence of results for spasticity management. For this patient, the finger flexor spasticity was greatly reduced.After BRI stim treatment, finger flexor spasticity has been reduced from MAs one plus to a minimum score of MAS equals zero. I'm 69 years of age, and in June 22nd I'll be 70. On May 5th, 2006, I suffered a major stroke and that left my whole entire right side paralyzed.My hand was just like this on my chest and I couldn't open it for a long time. And then with the little exercise I got so I could use my hand a little, then I met Dr.Shang Lee and he talked about some electronic intervention. So we went to his lab and he attached electrodes to my arm here that would stimulate the muscles of my right hand and with and be controlled by my breeding.And after 30 minutes of that, I found that I could open and close my hand with regularity with no problems whatsoever. And this has lasted for eight weeks and I feel that if anyone that has had a stroke can partake of the same type of intervention, that it will be of great benefit to them. After watching this video, you should have a good understanding of how to properly use voluntary breathing to trigger electrical stimulation and to improve its therapeutic efficacy.

breathing-controlled-electrical-stimulation-breestim-for-management

Research

JoVE Journal

Medicine

Source: Curado, M. et. al., Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function. J. Vis. Exp. (2016)This video demonstrates the setup and mechanism of transcranial direct current stimulation (tDCS) for modulating human motor function. By placing the anode over the primary motor cortex and the cathode over the contralateral supraorbital area, the targeted electrical stimulation increases cortical excitability, enhancing motor neuron activity and improving...

Non-Invasive Electrical Brain Stimulation for Modulating Human Motor Neuron Activity

Source: Remacle, T., et al. Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation. J. Vis. Exp. (2018)This video demonstrates the method of using multicolumn paddle lead spinal cord stimulation to manage chronic lower back pain in Failed back surgery syndrome (FBSS) patients. The pre-implanted lead delivers targeted electrical pulses that activate non-painful sensory pathways, interrupting pain signals and reducing pain perception.

Modulation of Chronic Pain Using Multicolumn Paddle Lead Spinal Cord Stimulation

Adaptive deep brain stimulation (aDBS) is effective for Parkinson’s disease, improving symptoms and reducing power consumption compared to conventional deep brain stimulation (cDBS). In aDBS we track a local field potential biomarker (beta oscillatory amplitude) in real time and use this to control the timing of stimulation.

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Non-invasive electrical brain stimulation can modulate cortical function and behavior, both for research and clinical purposes. This protocol describes different brain stimulation approaches for modulation of the human motor system.

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Treating chronic or neuropathic facial pain can be challenging when medical or standard treatment fails. Subcutaneous nerve field stimulation is the least invasive form of neuromodulation and is used for chronic back pain. We applied this technology to treat chronic and neuropathic trigeminal facial pain.

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Spinal cord injury is a traumatic medical condition that may result in elevated risks of chronic secondary metabolic disorders. Here, we presented a protocol using surface neuromuscular electrical stimulation-resistance training in conjunction with functional electrical stimulation-lower extremities cycling as a strategy to ameliorate several of these medical problems.

Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury

Existing approaches for constructing chronically implantable peripheral nerve cuff electrodes for use in small rodents often require specialized equipment and/or highly trained personnel. In this protocol we demonstrate a simple, low-cost approach for fabricating chronically implantable cuff electrodes, and demonstrate their effectiveness for vagus nerve stimulation (VNS) in rats.

Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats

Deep brain stimulation triggered by a patient-specific neural biomarker of a high-symptom state may better control symptoms of major depressive disorder compared to continuous, open-loop stimulation. This protocol provides a workflow for identifying a patient-specific neural biomarker and controlling the delivery of therapeutic stimulation based on the identified biomarker.

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder

The current study is a randomized, placebo-controlled trial to determine the efficacy of cranial electrical stimulation (CES) for improving pain and function in fibromyalgia and further develop resting functional connectivity magnetic resonance imaging (rs-fcMRI) as a clinical tool to assess the neural correlates and mechanisms of chronic pain and analgesic response.

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Programmed electrical stimulation provides the ability to determine conduction properties of the heart, and the possibility to induce and terminate cardiac arrhythmias using various pacing protocols. Using a transvenous catheter, intracardiac electrogram recordings can be obtained in mice following programmed electrical stimulation protocols to identify arrhythmogenic substrates.

Programmed Electrical Stimulation in Mice

Learn BreEStim for managing neuropathic pain and spasticity using breathing-controlled electrical stimulation. This method synchronizes voluntary inhalation with targeted pulses to enhance therapeutic efficacy and improve patient outcomes.

Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity

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