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Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
JoVE Journal
Behavior
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JoVE Journal Behavior
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

DOI:
10.3791/50358-v

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14:21 min

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August 06, 2013

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, , , , , ,
1Diagnostic Radiology,Yale University, 2Psychiatry,Yale University, 3Yale PET Center,Yale University, 4Biomedical Engineering,Yale University, 5Nuclear Medicine,Massachusetts General Hospital, 6Radiological Sciences,University of California, Irvine

Chapters

  • 00:05Title
  • 03:08Preparation for PET
  • 04:16PET Acquisition
  • 05:26Image Processing
  • 09:51Results: Ip-ntPET and Cigarette Smoking
  • 12:24Conclusion

Summary

Automatic Translation

Automatic Translation

We present a novel PET imaging approach for capturing dopamine fluctuations induced by cigarette smoking. Subjects smoke in the PET scanner. Dynamic PET images are modeled voxel-by-voxel in time by lp-ntPET, which includes a time-varying dopamine term. The results are 'movies' of dopamine fluctuations in the striatum during smoking.

Tags

Keywords: Dynamic PETDopamine FluctuationsCigarette SmokingLp-ntPETTime-varying ParametersHYPR Spatial FilterStatistical ComparisonVoxel-level ModelingDopamine Movie

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