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JoVE Journal
Immunology and Infection

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Peptide-based Identification of Functional Motifs and their Binding Partners
 

Peptide-based Identification of Functional Motifs and their Binding Partners

Article doi: 10.3791/50362
June 30th, 2013

Summary June 30th, 2013

Techniques to dissect the mechanisms underlying the secretion of HIV-1 Nef in exosomes are described. Specific short peptides derived from Nef and protein transfection were exploited to determine the structure, function, and binding partners of Nef’s Secretion Modification Region. These procedures have general relevance in many mechanistic studies.

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