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08:22 min
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July 21, 2013
DOI:
1Department of Neurobiology & Behavior,University of California, Irvine, 2The Center for the Neurobiology of Learning and Memory,University of California, Irvine, 3The Center for Hearing Research,University of California, Irvine, 4Department of Biomedical Engineering,University of California, Irvine
Summary
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We describe a highly reproducible method for the permanent occlusion of a rodent major cerebral blood vessel. This technique can be accomplished with very little peripheral damage, minimal blood loss, a high rate of long-term survival, and consistent infarct volume commensurate with the human clinical population.
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Cite this Article
Davis, M. F., Lay, C., Frostig, R. D. Permanent Cerebral Vessel Occlusion via Double Ligature and Transection. J. Vis. Exp. (77), e50418, doi:10.3791/50418 (2013).
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