Medicine
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Cell Death Associated with Abnormal Mitosis Observed by Confocal Imaging in Live Cancer Cells
Chapters
Summary August 21st, 2013
The cytotoxic activity of the phenanthridine PJ-34 in cancer cells undergoing mitosis was documented in real time by live confocal imaging. PJ-34 eradicated human breast cancer MDA-MB-231 cells harboring extra-centrosomes in mitosis. Unlike normal bi-focal mitosis, the extra-centrosomes were not clustered in the two spindle poles in the presence of PJ-34.
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