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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

DOI:
10.3791/50668-v

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14:20 min

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June 13, 2014

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, , , , , , , , , ,
1Nanomedicine Research Center, Department of Neurosurgery,Cedars-Sinai Medical Center

Chapters

  • 00:05Title
  • 02:34Bioproduction of Polymalic Acid
  • 04:56Synthesis of Polymalic Acid-based Nano Drug
  • 08:48Assays and Properties
  • 10:48Results: Silencing of the Human HER2-positive Breast Cancer
  • 13:12Conclusion

Summary

Automatic Translation

Automatic Translation

An example of a nano drug based on polymalic acid is presented towards the rational design of personalized medicine that is applicable to cancer. It describes the synthesis of a nano drug to treat Her2-positive human breast cancer in a nude mouse.

Tags

Keywords: Polymalic AcidNano BiopolymersTumor MarkersPersonalized MedicineHer2-positive Breast CancerAntisense OligonucleotidesTumor TargetingBiodegradableNon-toxicNon-immunogenicMouse Model

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