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1The Markey Cancer Center,University of Kentucky College of Medicine, 2Graduate Center for Toxicology,University of Kentucky College of Medicine, 3Department of Molecular and Biomedical Pharmacology,University of Kentucky College of Medicine, 4Department of Pediatrics,University of Kentucky College of Medicine
Chapters
- 00:05Title
- 02:12Preparation of C57Bl/6 K14-Scf Mice and Topical Forskolin Treatment
- 04:31Reflective Colorimetry and Calculating the Minimal Erythematous Dose
- 08:15Representative Melanin Induction Results
- 11:43Conclusion
Epidermal melanin induceres ved lokal applikation af forskolin i en murin model af fair-flået UV-følsomme menneske. Farmakologisk manipulation af cAMP-niveauer i huden og epidermal mørkfarvning kraftigt beskytte mod UV-medieret inflammation (solskoldning) som målt af den minimale erytematøse dosis (MED) assay.
