Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Daniel A. Lee; Juan Salvatierra; Esteban Velarde; John Wong; Eric C. Ford; Seth Blackshaw

doi:10.3791/50716

Journal

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Neuroscience

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Interrogatório funcional do Adulto Hypothalamic Neurogenesis com Focal Radiológica Inibição

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Interrogatório funcional do Adulto Hypothalamic Neurogenesis com Focal Radiológica Inibição

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12,104 Views

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11:45 min

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November 14, 2013

DOI:

10.3791/50716-v

DOI:

10.3791/50716-v

•

11:45 min

November 14, 2013

•

1 Views

Daniel A. Lee^1,2, Juan Salvatierra², Esteban Velarde³, John Wong³, Eric C. Ford⁴, Seth Blackshaw^2,5

¹Division of Biology,California Institute of Technology, ²Solomon H. Snyder Department of Neuroscience, Neurology, and Ophthalamology,Johns Hopkins University School of Medicine, ³Department of Radiation Oncology & Molecular Radiation Sciences,Johns Hopkins University School of Medicine, ⁴Department of Radiation Oncology,University Of Washington Medical Center, ⁵Institute for Cell Engineering and High-Throughput Biology Center,Johns Hopkins University School of Medicine

Summary

A função dos neurônios de mamíferos nascido de adultos continua a ser uma área ativa de pesquisa. A radiação ionizante inibe o nascimento de novos neurônios. Usando computador guiada por tomografia irradiação focal (CFIR), segmentação anatômica tridimensional de populações específicas progenitoras neurais agora pode ser usado para avaliar o papel funcional da neurogênese adulta.