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JoVE Journal
Immunology and Infection

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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
 

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Article DOI: 10.3791/50765
September 26th, 2013

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Summary September 26th, 2013

With effector functions distinct from other T cell subsets, Th17 cells have been centrally implicated in inflammatory autoimmunity. This in vitro Th17 differentiation protocol provides a means to determine whether naïve CD4+ T lymphocytes can differentiate into Th17 cells, and to further examine their role in autoimmunity and host response.

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