Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism

Jacklyn D. Smith; Jong M. Rho; Susan A. Masino; Richelle Mychasiuk

doi:10.3791/50791

Journal

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Behavior

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Inchworming: A Novel Motor Stereotypy in the BTBR T⁺ Itpr3^tf/J Mouse Model of Autism

Inchworming: A Novel Motor Stereotypy in the BTBR <em>T<sup>+</sup> Itpr3<sup>tf</sup></em>/J Mouse Model of Autism

JoVE Journal
Behavior

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JoVE Journal Behavior

Inchworming: A Novel Motor Stereotypy in the BTBR T⁺ Itpr3^tf/J Mouse Model of Autism

Inchworming: A Novel Motor Stereotypy in the BTBR T⁺ Itpr3^tf/J Mouse Model of Autism

11,523 Views

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08:03 min

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July 05, 2014

DOI:

10.3791/50791-v

DOI:

10.3791/50791-v

•

08:03 min

July 05, 2014

•

4 Views

Jacklyn D. Smith¹, Jong M. Rho¹, Susan A. Masino², Richelle Mychasiuk¹

¹Departments of Paediatrics and Clinical Neurosciences, Alberta Children’s Hospital Research Institute,University of Calgary Faculty of Medicine, ²Department of Psychology, Neuroscience Program,Trinity College

Summary

Inchworming is a highly repetitive synchronous digging motion displayed by BTBR T⁺ Itpr^3tf/J (BTBR) mice when placed in a testing cage with sufficient sawdust bedding. The procedure is a modification of the juvenile social interaction protocol and is used here to assess repetitive motor stereotypies relevant to Autism Spectrum Disorder.