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Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism
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JoVE Journal Behavior
Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism

Inchworming: A Novel Motor Stereotypy in the BTBR T+ Itpr3tf/J Mouse Model of Autism

DOI:
10.3791/50791-v

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08:03 min

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July 05, 2014

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, , ,
1Departments of Paediatrics and Clinical Neurosciences, Alberta Children’s Hospital Research Institute,University of Calgary Faculty of Medicine, 2Department of Psychology, Neuroscience Program,Trinity College

Chapters

  • 00:04Title
  • 01:28Animal and Equipment Preparation
  • 02:49Testing Procedure
  • 04:05Data Analysis
  • 06:50Results: Autistic Mouse Model Displays Increased Inchworming Behavior
  • 07:28Conclusion

Summary

Automatic Translation

Automatic Translation

Inchworming is a highly repetitive synchronous digging motion displayed by BTBR T+ Itpr3tf/J (BTBR) mice when placed in a testing cage with sufficient sawdust bedding. The procedure is a modification of the juvenile social interaction protocol and is used here to assess repetitive motor stereotypies relevant to Autism Spectrum Disorder.

Tags

Keywords: InchwormingMotor StereotypyBTBR T+ Itpr3tf/J MouseAutism Spectrum DisorderRepetitive BehaviorJuvenile Social InteractionC56BL/6J Mouse

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