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Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

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11:37 min

November 29, 2013

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11:37 min
November 29, 2013

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Protein conformation and dynamics are key to understanding the relationship between protein structure and function. Hydrogen exchange coupled with high-resolution mass spectrometry is a versatile method to study the conformational dynamics of proteins as well as characterizing protein-ligand and protein-protein interactions, including contact interfaces and allosteric effects.

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