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Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Article DOI: 10.3791/50839
November 29th, 2013 •
1, 1
1Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), University of Heidelberg

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November 29th, 2013

Protein conformation and dynamics are key to understanding the relationship between protein structure and function. Hydrogen exchange coupled with high-resolution mass spectrometry is a versatile method to study the conformational dynamics of proteins as well as characterizing protein-ligand and protein-protein interactions, including contact interfaces and allosteric effects.

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