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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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Medicine
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JoVE Journal Medicine
An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

DOI:
10.3791/50873-v

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06:48 min

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September 18, 2013

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, ,
1Department of Medicine,Northwestern University, 2Robert H. Lurie Cancer Center,Northwestern University, 3Center for Molecular Innovation and Drug Discovery,Northwestern University

Chapters

  • 00:05Title
  • 01:32Orthotopic Implantation of Human Prostate Cancer Cells
  • 02:35Necropsy Procedures
  • 03:39Results: Identification and Quantification of Metastases in a Murine Human Pancreatic Cancer Model
  • 06:27Conclusion

Summary

Automatic Translation

Automatic Translation

This orthotopic model of human prostate cancer allows for quantification of tumor size, circulating tumor cells, and formation of distinct metastasis to the lung. As cells must escape the primary organ, enter the blood stream, and implant into a secondary site, this model effectively recapitulates the scenario in humans.

Tags

Keywords: Prostate CancerOrthotopic ModelMetastasisPreclinical ModelCirculating Tumor CellsLung MetastasisTherapeutic Response

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