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Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer’s Disease and Normal Elderly
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Medicine
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JoVE Journal Medicine
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer’s Disease and Normal Elderly

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer’s Disease and Normal Elderly

DOI:
10.3791/50887-v

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12:50 min

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April 14, 2014

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, , , , , ,
1LC Campbell Cognitive Neurology Research Unit, Heart & Stroke Foundation Canadian Partnership for Stroke Recovery, Brain Sciences Research Program,Sunnybrook Health Sciences Centre, 2Department of Medicine (Neurology), Institute of Medical Science,University of Toronto

Chapters

  • 00:05Title
  • 02:31Brain-Sizer Component TIV-extraction
  • 03:49Ventricular Reassignment
  • 04:45Removal of Brain Stem, Cerebellum, and Subtentorial Structures
  • 05:50SABRE Component: ACPC Alignment
  • 07:01SABRE Landmark Identification
  • 09:31Lesion-Seg Component
  • 10:38Results: Example Lesion Explorer Brain Volumetrics
  • 11:49Conclusion

Summary

Automatic Translation

Automatic Translation

Lesion Explorer (LE) is a semi-automatic, image-processing pipeline developed to obtain regional brain tissue and subcortical hyperintensity lesion volumetrics from structural MRI of Alzheimer's disease and normal elderly. To ensure a high level of accuracy and reliability, the following is a video-guided, standardized protocol for LE's manual procedures.

Tags

Keywords: MRI-derived VolumetricsAlzheimer’s DiseaseNormal ElderlyLesion ExplorerBrain-SizerSABRELesion-SegTotal Intracranial VaultVentricular Cerebrospinal FluidAnterior And Posterior CommissureSubcortical HyperintensitiesVideo-guided ProtocolStandardized ProcedureAccuracyReliability

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