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In Vivo Imagem Óptico de tumores cerebrais e artrite Usando fluorescente SAPC-DOPS nanovesículas
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In Vivo Imagem Óptico de tumores cerebrais e artrite Usando fluorescente SAPC-DOPS nanovesículas

Article DOI: 10.3791/51187-v • 09:04 min • May 2nd, 2014
May 2nd, 2014 •
1,2, 3, 1, 5,6, 5,6, 4, 4, 3, 1,2
1Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, 2Division of Human Genetics, University of Cincinnati College of Medicine, 3Department of Radiology, University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center

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Descreve-se um sistema (Maroi) para in vivo quantificação de um marcador fluorescente entregue por saposina C (SAPC)-dioleoylphosphatidylserine (DOPS) nanovesículas multi-ângulo de rotação de imagem óptica. Utilizando modelos de ratinho de cancro e artrite, é mostrado como a análise da curva de sinal Maroi pode ser utilizado para o mapeamento preciso e caracterização biológica de processos de doença.

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Medicina Edição 87 a saposina C (SAPC) Dioleoylphosphatidylserine (DOPS) tumor cerebral artrite Fluoróforo fluorescência a imagem óptico Multi-ângulo de rotação de imagem óptica (Maroi)
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