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Barnes Maze Testing Strategies with Small and Large Rodent Models
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JoVE Journal Behavior
Barnes Maze Testing Strategies with Small and Large Rodent Models

Barnes Maze Testing Strategies with Small and Large Rodent Models

DOI:
10.3791/51194-v

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12:59 min

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February 26, 2014

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1Biomedical Sciences and Bond Life Sciences Center,University of Missouri, 2Division of Neurotoxicology, National Center for Toxicological Research,Food and Drug Administration

Chapters

  • 00:05Title
  • 01:27Overview of the Barnes Maze for Small Rodents
  • 02:58Running the Barnes Maze with Mice
  • 05:50Setting up the Barnes maze for Rats Without Tracking
  • 07:20Running the Barnes Maze with Rats
  • 09:46Results: Maze Assessment of Polygamous and Monogamous Mice Fed Bisphenol A Supplemented Diets
  • 12:23Conclusion

Summary

Automatic Translation

Automatic Translation

The dry-land Barnes maze is widely used to measure spatial navigation ability in response to mildly aversive stimuli. Over consecutive days, performance (e.g. latency to locate escape cage) of control subjects improves, indicative of normal learning and memory. Differences between rats and mice necessitate apparatus and methodology changes that are detailed here.

Tags

Keywords: Barnes MazeSpatial LearningSpatial MemoryRodentsMiceRatsNavigationWater MazeExtra-maze CuesIntra-maze CuesSearch StrategyLatencyDistance TraveledVelocityTime SpentAutomated Tracking

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