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JoVE Journal
Bioengineering

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Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
 

Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

Article DOI: 10.3791/51254
June 3rd, 2014

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Summary June 3rd, 2014

We present a combination of Cryo-electron microscopy, lipid nanotechnology, and structure analysis applied to resolve the membrane-bound structure of two highly homologous FVIII forms: human and porcine. The methodology developed in our laboratory to helically organize the two functional recombinant FVIII forms on negatively charged lipid nanotubes (LNT) is described.

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