Technique of Subnormothermic <em>Ex Vivo</em> Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Jan M. Knaak; Vinzent N. Spetzler; Nicolas Goldaracena; Kristine S. Louis; Nazia Selzner; Markus Selzner

doi:10.3791/51419

Journal

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Medicine

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Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Technique of Subnormothermic <em>Ex Vivo</em> Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

JoVE Journal
Medicine

This content is Free Access.

JoVE Journal Medicine

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

14,707 Views

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09:29 min

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August 13, 2014

DOI:

10.3791/51419-v

DOI:

10.3791/51419-v

•

09:29 min

August 13, 2014

•

26 Views

Jan M. Knaak*^1,2, Vinzent N. Spetzler*^1,2, Nicolas Goldaracena^1,2, Kristine S. Louis^1,2, Nazia Selzner^1,3, Markus Selzner^1,2

¹Multi Organ Transplant Program,Toronto General Hospital, ²Department of Surgery,Toronto General Hospital, ³Department of Medicine,Toronto General Hospital

Summary

Marginal grafts, such as fatty livers, grafts from older donors, or livers retrieved after cardiac death (DCD) tolerate conventional, cold static storage only poorly. We developed a novel model of subnormothermic ex vivo liver perfusion for preservation, assessment, and repair of marginal liver grafts prior to transplantation.