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11:27 min
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April 29, 2014
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Summary
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Models of spontaneous metastatic renal cell carcinoma (RCC) disease progression can be used for evaluating treatments in a clinically relevant setting. This protocol demonstrates different procedures for orthotopic kidney tumor cell implantation, proper nephrectomy, and finally outlines a necropsy guide for visual and bioluminescent scoring of metastatic burden and localization.
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Cite this Article
Tracz, A., Mastri, M., Lee, C. R., Pili, R., Ebos, J. M. L. Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy. J. Vis. Exp. (86), e51485, doi:10.3791/51485 (2014).
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