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Chapters
- 00:05Title
- 02:13Orthotopic Kidney Tumor Implantation
- 05:37Nephrectomy/Primary Tumor Removal
- 06:51Monitoring Metastatic Progression and Localization at Endpoint
- 09:47Results: Assessment of Metastasis Location and Severity
- 10:19Conclusion
Models of spontaneous metastatic renal cell carcinoma (RCC) disease progression can be used for evaluating treatments in a clinically relevant setting. This protocol demonstrates different procedures for orthotopic kidney tumor cell implantation, proper nephrectomy, and finally outlines a necropsy guide for visual and bioluminescent scoring of metastatic burden and localization.
