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JoVE Journal
Immunology and Infection

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Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
 

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Article DOI: 10.3791/51724
July 25th, 2014

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Summary July 25th, 2014

Tail-skin transplantation is a powerful model for studying T cell-dependent rejection and tolerance induction during allogeneic immune responses in mice. The advantages of this protocol are minor invasive surgery, and ease of monitoring with no need to sacrifice the recipient mouse.

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