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Immunology and Infection

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JoVE Journal Immunology and Infection
Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells
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Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Article DOI: 10.3791/51859 • 08:12 min • August 11th, 2014
August 11th, 2014 •
1, 2,3, 1, 1
1Department of Pathology, Institute of Cell Engineering, Johns Hopkins University, 2Department of Internal Medicine I, University of Regensburg, 3Department of Rheumatology, Asklepios Medical Center

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Summary
Automatic Translation

Guidelines are presented for the generation of killer artificial antigen presenting cells, KaAPC, an efficient tool for in vitro depletion of human antigen-specific T cells and an alternative solution to cellular immunotherapy for the treatment of T cell-mediated autoimmune diseases in an antigen-specific fashion without compromising the remaining immune system.

Tags

Killer Artificial Antigen Presenting Cells KaAPC In Vitro Depletion Human Antigen-specific T Cells T Cell Mediated Autoimmune Diseases Global Immunosuppression Adverse Side Effects Disease Mediating Cells Immune System Intact Cell-based Immunotherapy Strategies Tolerance-inducing Antigen Presenting Cells Cytotoxic T Cell Responses Therapeutic Capacity Non-cellular Killer Artificial Antigen Presenting Cells Autoimmune Diseases Allograft Rejections Antigen Specific Fashion
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