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11:14 min
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September 24, 2014
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Summary
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The brain is a unique site with qualities that are not well represented by in vitro or ectopic analyses. Orthotopic mouse models with reproducible location and growth characteristics can be reliably created with intracranial injections using a stereotaxic fixation instrument and a low pressure syringe pump.
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Cite this Article
Pierce, A. M., Keating, A. K. Creating Anatomically Accurate and Reproducible Intracranial Xenografts of Human Brain Tumors. J. Vis. Exp. (91), e52017, doi:10.3791/52017 (2014).
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