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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Article DOI: 10.3791/52018
October 29th, 2014 •
1, 1, 1, 2, 1
1School of Pharmacy, University College London, 2Mucin Biology Group, University of Gothenburg

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October 29th, 2014

Here, a procedure is described for the establishment of systemic infection in the neonatal rat with cultures of Escherichia coli K1. This non-invasive procedure permits colonization of the gastrointestinal tract, translocation of the pathogen to the systemic circulation, and invasion of the central nervous system at the choroid plexus.

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