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Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
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Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

DOI:
10.3791/52105-v

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11:57 min

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February 23, 2015

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, , , ,
1Department of Genetics and Development, Toronto Western Research Institute and Spinal Program,University Health Network, Krembil Neuroscience Centre, 2Department of Surgery,University of Toronto, 3Institute of Medical Sciences,University of Toronto

Chapters

  • 00:05Title
  • 01:20Induction of Cervical Clip Contusion
  • 05:36Injection of Self-assembling Peptides (SAPs)
  • 07:03Injection of Neural Precursor Cells (NPCs)
  • 08:34Implantation of Subdural Pumps for Growth Factor Application
  • 10:39Results: Successful Delivery of SAPs and NPCs and Scaffold Formation
  • 11:27Conclusion

Summary

Automatic Translation

Automatic Translation

Treating cervical spinal cord injury with both self-assembling peptides (SAP) and neural precursor cells (NPC), together with growth factors, is a promising approach to promote regeneration and recovery. A contusion/compression aneurysm clip rat model of cervical SCI and combined treatment involving SAP injection and NPC transplantation is established.

Tags

Keywords: Spinal Cord InjuryCervical SpineSecondary MechanismsInflammationApoptosisDemyelinationIntramedullary CavitiesSelf-assembling PeptidesNeural Precursor CellsGrowth FactorsNanofibersScaffoldRegeneration

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