JoVE Journal
Medicine
Medicine
A subscription to JoVE is required to view this content.
You will only be able to see the first 20 seconds.
Summary January 4th, 2015
Mechanical rigidity in the tumor microenvironment plays a crucial role in driving malignant behavior by increasing invadopodia activity and actomyosin contractility. Using polyacrylamide gels (PAAs), invadopodia and traction force assays can be utilized to study the invasive and contractile properties of cancer cells in response to matrix rigidity.
