Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Padmavathy Nandha Premnath; Sandra Craig; Campbell McInnes

doi:10.3791/52441

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

JoVE Journal
Biology

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JoVE Journal Biology

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

11,249 Views

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10:33 min

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October 26, 2015

DOI:

10.3791/52441-v

DOI:

10.3791/52441-v

•

10:33 min

October 26, 2015

•

2 Views

Padmavathy Nandha Premnath¹, Sandra Craig¹, Campbell McInnes¹

¹Department of Drug Discovery and Biomedical Sciences,University of South Carolina

Summary

We describe implementation of the REPLACE strategy for targeting protein-protein interactions. REPLACE is an iterative strategy involving synthetic and computational approaches for the conversion of optimized peptidic inhibitors into drug like molecules.