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JoVE Journal
Biology

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Development of Inhibitors of Protein-protein Interactions through REPLACE
 

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Article DOI: 10.3791/52441
October 26th, 2015

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Summary October 26th, 2015

We describe implementation of the REPLACE strategy for targeting protein-protein interactions. REPLACE is an iterative strategy involving synthetic and computational approaches for the conversion of optimized peptidic inhibitors into drug like molecules.

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