A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Aaron Topol; Ngoc N. Tran; Kristen J. Brennand

doi:10.3791/52495

Journal

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Medicine

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A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

JoVE Journal
Medicine

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JoVE Journal Medicine

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

18,136 Views

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09:30 min

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February 21, 2015

DOI:

10.3791/52495-v

DOI:

10.3791/52495-v

•

09:30 min

February 21, 2015

•

9 Views

Aaron Topol¹, Ngoc N. Tran¹, Kristen J. Brennand^1,2

¹Department of Psychiatry,Icahn School of Medicine at Mount Sinai, ²Department of Neuroscience,Icahn School of Medicine at Mount Sinai

Summary

This protocol describes how neural progenitor cells can be differentiated from human induced pluripotent stem cells, in order to yield a robust and replicative neural cell population, which may be used to identify the developmental pathways contributing to disease pathogenesis in many neurological disorders.