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JoVE Journal
Bioengineering

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Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
 

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Article doi: 10.3791/52621
April 28th, 2015

Summary April 28th, 2015

This protocol describes the synthesis of biofunctionalized Prussian blue nanoparticles and their use as multimodal, molecular imaging agents. The nanoparticles have a core-shell design where gadolinium or manganese ions within the nanoparticle core generate MRI contrast. The biofunctional shell contains fluorophores for fluorescence imaging and targeting ligands for molecular targeting.

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