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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
 

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Article DOI: 10.3791/52978
August 18th, 2015

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Summary August 18th, 2015

Thromboembolic stroke models are vital tools for optimizing the recanalization therapy. Here we report a murine thrombotic stroke model based on transient cerebral hypoxic-ischemic (tHI) insult, which triggers thrombosis and infarction, and responds favorably to tissue plasminogen activator (tPA)-mediated fibrinolysis in a therapeutic window similar to those in stroke patients.

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