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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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JoVE Journal Medicine
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

DOI:
10.3791/52978-v

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06:01 min

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August 18, 2015

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,
1Department of Pediatrics, Division of Neurology,The Emory University School of Medicine

Chapters

  • 00:05Title
  • 01:40Transient Cerebral Hypoxia-ischemia
  • 03:54Laser Speckle Contrast Imaging (LSCI)
  • 04:43Tissue Plasminogen Activator (tPA) Administration and Brian Damage Detection
  • 05:28Conclusion

Summary

Automatic Translation

Automatic Translation

Thromboembolic stroke models are vital tools for optimizing the recanalization therapy. Here we report a murine thrombotic stroke model based on transient cerebral hypoxic-ischemic (tHI) insult, which triggers thrombosis and infarction, and responds favorably to tissue plasminogen activator (tPA)-mediated fibrinolysis in a therapeutic window similar to those in stroke patients.

Tags

Keywords: Thrombotic Stroke ModelTransient Cerebral Hypoxia-ischemiaTPAReperfusion DeficitsFibrin And Platelet DepositionMiddle Cerebral ArteryPreclinical Stroke Research

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