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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
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Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Article DOI: 10.3791/52981-v • 09:37 min • October 23rd, 2015
October 23rd, 2015 •
1, 2,3, 1, 1,2
1Department of Biomedical Engineering, Texas A&M University, 2Department of Material Science and Engineering, Texas A&M University, 3Institute of Advanced Materials and Technology, University of Science & Technology Beijing

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Summary
Automatic Translation

Scaffolds capable of fitting within cranio-maxillofacial (CMF) bone defects while exhibiting osteoconductivity and bioactivity are of interest. This protocol describes the preparation of a shape memory scaffold based on polycaprolactone diacrylate (PCL-DA) using a solvent-casting particulate-leaching (SCPL) method employing a fused salt template and application of a bioactive polydopamine coating.

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Bioactive PCL-based Self-fitting Shape Memory Polymer Scaffold Tissue Engineering Cranio-maxillofacial Bone Defects Biodegradability Pore Interconnectivity Bioactivity Shape Memory Polymer (SMP) Warm Saline Malleable Irregular Defect Hand-pressed Cooling Rigid State Photochemical Cure Polycaprolactone Diacrylate (PCL-DA) Solvent-casting Particulate-leaching (SCPL) Fused Salt Template Polydopamine Coating Characterization In Vitro Bioactivity
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