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JoVE Journal
Bioengineering
Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Full Text
11,151 Views
09:56 min
December 8, 2015

DOI: 10.3791/53279-v

Hyun-Do Jung1, Hyun Lee2, Hyoun-Ee Kim2,3, Young-Hag Koh4, Juha Song3

1Liquid Processing & Casting Technology R&D Group,Korea Institute of Industrial Technology, 2Department of Materials Science and Engineering,Seoul National University, 3Advanced Institutes of Convergence Technology,Seoul National University, 4School of Biomedical Engineering,Korea University

Bioactive and mechanically reliable metal scaffolds have been fabricated through a method which consists of two processes, dynamic freeze casting for the fabrication of porous Ti, and coating and densification of the Ti scaffolds. The densification process is simple, effective and applicable to the fabrication of functionally graded scaffolds.

The overall goal of this procedure is to fabricate mechanically tunable and bioactive metal scaffolds for biomedical applications. This method can help answer key questions in the orthopedic implant field, such as the feasibility of a mechanical tuneable metal scaffold that is capable of delivering drugs. This gentrification method is simple because it requires only one control.

Parameters achieve both mechanical enhancement and the sustainable drug release and is capable to the fabrication of functionality created por oid First mix the appropriate amounts of titanium powder, caffeine, and KD four for porous titanium scaffolds with four initial porosities in 500 milliliter polyethylene bottles. Rotate the bottles in a ball mill oven at a speed of 30 RPM at 55 degrees Celsius for 30 minutes. Pour the slurries from the polyethylene bottles into cylindrical aluminum molds with a diameter and height of 60 millimeters.

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