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Immunology and Infection

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An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Article DOI: 10.3791/53288 • 09:25 min • December 24th, 2015
December 24th, 2015 •
1, 1
1Department of Medicine, Harvard Medical School - BIDMC

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Summary
Automatic Translation

Adaptive immunity is controlled by dynamic 'immunological synapses' formed between T cells and antigen presenting cells. This protocol describes methods for investigating endothelial cells both as understudied physiologic APCs and as a novel type of 'planar cellular APC model'.

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Endothelial Planar Cell Model Imaging Immunological Synapse Dynamics Adaptive Immunity T Cells Antigen Presenting Cells Immunological Synapses MHC/Ag-TCR Clusters F-actin Adhesion Molecules Signaling Molecules Immune Responses Protective Immunity Pathologic Immunity Imaging Resolution Artificial Substrate Models Planar Lipid Bilayers Vascular Endothelial Cells Lymphatic Endothelial Cells Semi-professional APCs Molecular Machinery Of Professional APCs Planar Cellular APC Model
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