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A Neonatal Mouse Spinal Cord Compression Injury Model
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A Neonatal Mouse Spinal Cord Compression Injury Model

A Neonatal Mouse Spinal Cord Compression Injury Model

DOI:
10.3791/53498-v

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13:31 min

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March 27, 2016

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, ,
1Department of Neurosurgery,Oslo University Hospital, 2Norwegian Center for Stem Cell Research,Oslo University Hospital, 3Laboratory of Neural Development and Optical Recording (NDEVOR), Department of Physiology, Institute of Basic Medical Sciences,University of Oslo

Chapters

  • 00:00Title
  • 01:14Preparing for the Surgery
  • 03:52Anesthesia and Analgesia
  • 08:04Dorsal Laminectomy
  • 10:20Generating the Spinal Cord Compression Injury
  • 11:17Suturing
  • 12:05Results
  • 12:48Conclusion

Summary

Automatic Translation

Automatic Translation

This article describes a method for generating a reproducible spinal cord compression injury (SCI) in the neonatal mouse. The model provides an advantageous platform for studying mechanisms of adaptive plasticity that underlie spontaneous functional recovery.

Tags

Keywords: Neonatal MouseSpinal Cord CompressionInjury ModelLaminectomyYasargil Temporary Aneurysm MiniclipCompression InjurySurgical ProcedureAnesthesiaAnalgesiaAdaptive Plasticity

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