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A Mouse Model for Laser-induced Choroidal Neovascularization
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A Mouse Model for Laser-induced Choroidal Neovascularization

A Mouse Model for Laser-induced Choroidal Neovascularization

DOI:
10.3791/53502-v

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07:08 min

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December 27, 2015

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, , ,
1Department of Ophthalmology,Northwestern University Feinberg School of Medicine

Chapters

  • 00:05Title
  • 00:54Mouse and Laser Preparation
  • 02:28Laser Induction of Choroidal Neovascularization (CNV)
  • 05:32Results: Visualization and Quantification of CNV Lesions
  • 06:29Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we present the mouse laser-induced choroidal neovascularization (CNV) protocol, an experimental model that re-creates the vascular hallmarks of neovascular age-related macular degeneration (AMD). Once mastered, it can reliably and effectively induce CNV as a model system to test various experimental measures.

Tags

Keywords: Mouse ModelLaser-induced Choroidal NeovascularizationNeovascular Age-related Macular DegenerationRPEBruch’s MembraneAngiogenesisTransgenic ModelsLaser ProcedureMolecular MechanismsGenetic ManipulationsDrug Treatment EffectsPathologyChorio-retinal EnvironmentPathogenesis

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