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Facile Preparation of 4-Substituted Quinazoline Derivatives
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JoVE Journal Chemistry
Facile Preparation of 4-Substituted Quinazoline Derivatives

Facile Preparation of 4-Substituted Quinazoline Derivatives

DOI:
10.3791/53662-v

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11:51 min

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February 15, 2016

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, ,
1School of Science and Computer Engineering,University of Houston-Clear Lake, 2Airgas Specialty Gas,Airgas USA LLC

Chapters

  • 00:05Title
  • 00:51Preparation of 4-Phenylquinazoline in Small Scale Under Microwave Irradiation
  • 02:36GC/MS Analysis of Reactive Mixture
  • 06:44Purification of 4-Phenylquinazoline by Preparative Thin Layer Chromatography
  • 09:22Results: GC-MS Analysis to Monitor the Reaction at Different Times
  • 11:00Conclusion

Summary

Automatic Translation

Automatic Translation

A protocol for facile preparation of 4-substituted quinazoline derivatives from 2-aminobenzophenones, thiourea and dimethyl sulfoxide is presented.

Tags

4-Substituted Quinazoline DerivativesFacile PreparationReactionTwo-aminobenzophenoneUreaDimethyl SulfoxideChemistry-fieldMiniscale PreparationPurification TechniquesClean ReactionGas Chromatography-mass Spectroscopy (GC-mass)Product PurificationPreparative ChromatographyThin-layer Chromatography (TLC)Microwave Reaction TubeMagnetic Stir BarDMSOAluminum CapRubber Septum-inletVortexerMicrowave Reactor Parameters

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