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A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex
JoVE Journal
Behavior
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JoVE Journal Behavior
A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex

A Pressure Injection System for Investigating the Neuropharmacology of Information Processing in Awake Behaving Macaque Monkey Cortex

DOI:
10.3791/53724-v

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09:46 min

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March 14, 2016

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, ,
1Cognitive Neuroscience Laboratory,German Primate Center, 2Faculty of Biology and Psychology,Goettingen University

Chapters

  • 00:05Title
  • 00:45Overview of the Injection Process
  • 01:39Preparing the Injection/Recording System
  • 02:49Daily Preparation of the Injection/Recording System
  • 05:20Acute Recordings
  • 07:03Pharmacological Manipulation While Recording
  • 08:17Results: Effect of Scopolamine and Saline on Firing Rate
  • 09:11Conclusion

Summary

Automatic Translation

Automatic Translation

Here, we show the pressure injection of neuropharmacological substances during single-cell recording in an awake, behaving macaque monkey. This procedure allows pharmacological manipulation in the direct vicinity of a cortical recording site.

Tags

Pressure Injection SystemNeuropharmacologyInformation ProcessingAwake Behaving Macaque Monkey CortexCognitive NeuroscienceNeurotransmittersFeedforward Cortical Information ProcessingTop-down ModulationAgonistsAntagonistsSensory Information ProcessingAttentionRhesus MonkeyAnimal ModelSingle Cell RecordingsNeuropharmacological ManipulationStable Measurement Of Single Neuron ActivityRecording Site

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