A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Mouhsin M. Shafi; Susan Whitfield-Gabrieli; Catherine J. Chu; Alvaro Pascual-Leone; Bernard S. Chang

doi:10.3791/53727

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A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

JoVE Journal
Medicine

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JoVE Journal Medicine

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

11,141 Views

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08:23 min

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November 13, 2016

DOI:

10.3791/53727-v

DOI:

10.3791/53727-v

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08:23 min

November 13, 2016

•

11111 Views

Mouhsin M. Shafi^1,2,3, Susan Whitfield-Gabrieli⁴, Catherine J. Chu^1,5, Alvaro Pascual-Leone^1,2,3, Bernard S. Chang^1,2

¹Department of Neurology,Harvard Medical School ²Department of Neurology,Beth Israel Deaconess Medical Center ³Berenson-Allen Center for Noninvasive Brain Stimulation,Beth Israel Deaconess Medical Center ⁴Department of Brain and Cognitive Sciences,Massachusetts Institute of Technology ⁵Department of Neurology,Massachusetts General Hospital

Summary

Resting-state functional-connectivity MRI has identified abnormalities in patients with a wide range of neuropsychiatric disorders, including epilepsy due to malformations of cortical development. Transcranial Magnetic Stimulation in combination with EEG can demonstrate that patients with epilepsy have cortical hyperexcitability in regions with abnormal connectivity.