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Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
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JoVE Journal Chemistry
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

DOI:
10.3791/53760-v

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07:53 min

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April 26, 2016

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,
1Institute of Environment, Health, Risks and Futures,Cranfield University

Chapters

  • 00:05Title
  • 00:53Optimization of Emulsion Conditions
  • 03:21Preparation of Dacarbazine-loaded NLC
  • 04:35Results: Encapsulation of Dacarbazine Using NLC to Improve Therapeutic Profiling
  • 05:59Conclusion

Summary

Automatic Translation

Automatic Translation

The most commonly used method for nanostructured lipid carrier (NLC) synthesis involves oil-in-water emulsion, homogenization and solidification. This was modified here by applying high shear dispersion after solidification to achieve a NLC with desirable size, improved drug encapsulation and drug loading efficiency as a potential carrier for dacarbazine delivery.

Tags

Keywords: Nanostructured Lipid CarrierDacarbazineCancer Therapeutic AgentEncapsulationDrug DispersityDrug Release ControlEmulsionHomogenizationDynamic Light ScatteringTransmission Electron Microscopy

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